RESUMO
Anti-α-Gal responses may exert a protective effect in falciparum malaria. However, the biological role of such antibodies is still unknown during Plasmodium vivax infections. We investigated IgG and IgM responses to α-Gal in individuals with vivax malaria. Anti-α-Gal IgG and IgM levels were higher in these patients than in controls, but no significant correlation was found between parasitaemia and anti-α-Gal response, nor between this response and ABO blood group status. This is the first study to investigate anti-α-Gal antibodies in P. vivax-infected patients; a larger survey is necessary to achieve a better understanding of host immune response during vivax malaria.
Assuntos
Humanos , Adulto , Pessoa de Meia-Idade , Adulto Jovem , Plasmodium vivax/imunologia , Imunoglobulina G/sangue , Imunoglobulina M/sangue , Anticorpos Anti-Idiotípicos/sangue , Malária Vivax/sangue , Imunoglobulina G/imunologia , Imunoglobulina M/imunologia , Anticorpos Anti-Idiotípicos/metabolismo , Malária Vivax/imunologia , Pessoa de Meia-IdadeRESUMO
The Petasis condensation of vinylic or aromatic boronic acids, aromatic aldehydes, and amines is assisted by a hydroxy group adjacent to the aldehyde moiety. The products derived from salicylaldehydes and vinylboronic acids undergo cyclization to 2H-chromene compounds with ejection of amine upon heating. A catalytic preparation of 2H-chromenes using resin-bound amine is reported, allowing the convenient incorporation of a variety of components.
